Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain

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Title

Lipopolysaccharide-induced changes in the neurovascular unit in the preterm fetal sheep brain

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Description

Background: Exposure to inflammation during pregnancy can predispose to brain injury in premature infants. In the present study, we investigated the effects of prolonged exposure to inflammation on the cerebrovasculature of preterm fetal sheep. Methods: Chronically instrumented fetal sheep at 103-104 days of gestation (full term is ~ 147 days) received continuous low-dose lipopolysaccharide (LPS) infusions (100 ng/kg over 24 h, followed by 250 ng/kg/24 h for 96 h plus boluses of 1 μg LPS at 4...

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Format

Research paper

Research format

Journal article

Date created

2020-05-28

Creator

Disdier, C / Awa, F / Chen, X / Dhillon, SK / Galinsky, R / Davidson, Joanne / Lear, Christopher / Bennet, Laura / Gunn, Alistair / Stonestreet, BS

URL

http://hdl.handle.net/2292/51950

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