The role of calcium-permeable AMPA receptors and arc in secreted amyloid precursor protein alpha-mediated plasticity

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Title

The role of calcium-permeable AMPA receptors and arc in secreted amyloid precursor protein alpha-mediated plasticity

Content partner

University of Otago

Collection

Otago University Research Archive

Description

The orchestrated regulation of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype of glutamate receptors by neuronal activity and neuromodulators is critical to the expression of both long-term potentiation (LTP) and memory. In particular, GluA1-containing, Ca2+-permeable AMPAR (CP-AMPAR) comprise a unique role in these processes due to their transient, activity-regulated expression at the synapse. Importantly, many of the mechanisms which govern these processes are negat...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2020

Creator

Livingstone, Rhys

URL

https://hdl.handle.net/10523/10485

Related subjects

New Zealand / Alzheimer's Disease / Arc / AMPA receptor / Calcium-Permeable AMPA receptor / CP-AMPAR / Hippocampus / Long-term Potentiation / LTP / Immunohistochemistry / Immunocytochemistry / FUNCAT-PLA / sAPPα / Neurotrophin / Cell Culture / Protein Synthesis / Electrophysiology / Gene Expression / Neuron / Proximity Ligase Assay

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