Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation from Genome Sequencing

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Title

Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation from Genome Sequencing

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Description

Background - Spontaneous coronary artery dissection (SCAD) occurs when an epicardial coronary artery is narrowed or occluded by an intramural hematoma. SCAD mainly affects women and is associated with pregnancy and systemic arteriopathies, particularly fibromuscular dysplasia. Variants in several genes, such as those causing connective tissue disorders, have been implicated; however, the genetic architecture is poorly understood. Here, we aim to better understand the diagnostic yield of rare ...

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Date created

23 Nov, 2020

Creator

Keren J Carss / Anna A Baranowska / Javier Armisen / Thomas R Webb / Stephen E Hamby / Diluka Premawardhana / Abtehale Al-Hussaini / Alice Wood / Quanli Wang / Sri VV Deevi / Dimitrios Vitsios / Samuel H Lewis / Deevia Kotecha / Nabila Bouatia-Naji / Stephanie Hesselson / Siiri E Iismaa / Ingrid Tarr / Lucy McGrath-Cadell / David W Muller / Sally L Dunwoodie / Diane Fatkin / Robert M Graham / Eleni Giannoulatou / Nilesh J Samani / Slavé Petrovski / Carolina Haefliger / David Adlam

URL

https://figshare.com/articles/journal_contribution/Spontaneous_Coronary_Artery_Dissection_Insight...

Related subjects

spontaneous coronary artery dissection / genetics / sequencing / rare variants / UK biobank / Uncategorized

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