Injectable Thermoresponsive Gels Offer Sustained Dual Release of Bupivacaine Hydrochloride and Ketorolac Tromethamine For Up To Two Weeks

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Title

Injectable Thermoresponsive Gels Offer Sustained Dual Release of Bupivacaine Hydrochloride and Ketorolac Tromethamine For Up To Two Weeks

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The University of Auckland Library

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Description

Bupivacaine and ketorolac are commonly used in combination to reduce perioperative pain. This study aimed to develop and characterize an injectable system that offers simultaneous and prolonged release of bupivacaine and ketorolac. Formulations were prepared using poloxamer 407 with increasing concentrations of poloxamer 188 and sodium chloride. Small Angle X-ray Scattering (SAXS) experiments demonstrated that the poloxamers form gels with a cubic lattice arrangement regardless of the matrix ...

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Format

Research paper

Research format

Journal article

Date created

2021-5

Creator

Abdeltawab, Hani / Svirskis, Darren / Boyd, Ben J / Hill, Andrew / Sharma, Manisha

URL

https://hdl.handle.net/2292/55387

Related subjects

1115 Pharmacology and Pharmaceutical Sciences

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