Functional Hyperactivity in Long QT Syndrome Type 1 Pluripotent Stem Cell-Derived Sympathetic Neurons.

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Title

Functional Hyperactivity in Long QT Syndrome Type 1 Pluripotent Stem Cell-Derived Sympathetic Neurons.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Sympathetic activation is an established trigger of life-threatening cardiac events in long QT syndrome type 1 (LQT1). KCNQ1 loss-of-function variants, which underlie LQT1, have been associated with both cardiac arrhythmia and neuronal hyperactivity pathologies. However, the LQT1 sympathetic neuronal phenotype is unknown. Here we aimed to study human induced pluripotent stem cell (hiPSC)-derived sympathetic neurons (SNs) to evaluate neuronal functional phenotype in LQT1. We generated hiPSC-SN...

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Format

Research paper

Research format

Journal article

Date created

2021-6-18

Creator

Winbo, Annika / Ramanan, Suganeya / Eugster, Emily / Rydberg, Annika / Jovinge, Stefan / Skinner, Jonathan R / Montgomery, Johanna M

URL

https://hdl.handle.net/2292/55663

Related subjects

arrhythmia mechanisms / human induced pluripotent stem cells / long QT syndrome / sympathetic hyperactivity / sympathetic neurons / 0606 Physiology / 1116 Medical Physiology

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