Ocular SM exposure causes increased expression of COX-2, VEGF, MMP-9, and IL-8.

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Title

Ocular SM exposure causes increased expression of COX-2, VEGF, MMP-9, and IL-8.

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Description

The right eyes of New Zealand white rabbits were exposed to SM (~0.4 mg/L) vapor either for 5 min (shorter duration) or 7 min (longer duration) and the clinical progression of ocular injury was observed starting from day 1 (6 h) up to 28 days post-exposure, as detailed in the materials and methods section. The left eye was designated as the control eye and was exposed only to the dilution air. Corneas were dissected post euthanasia at day 1, day 3, day 7, day 14, and day 28 post-exposure and ...

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Image

Date created

12 Oct 2021

Creator

Dinesh G. Goswami / Neha Mishra / Rama Kant / Chapla Agarwal / Claire R. Croutch / Robert W. Enzenauer / Mark J. Petrash / Neera Tewari-Singh / Rajesh Agarwal

URL

https://plos.figshare.com/articles/figure/Ocular_SM_exposure_causes_increased_expression_of_COX-2...

Related subjects

post longer durations / may develop inflammation / findings would benefit / establish quantifiable endpoints / chemical warfare agent / exposure durations compared / induced corneal toxicity / mechanisms underlying sm / div >< p / sm exposure led / ocular sm exposure / rabbits </ p / induced corneal injury / mmp )- 9 / cox )- 2 / sm exposure / vivo </ / corneal thickness / corneal structure / exposure duration / temporal delineation / sulfur mustard / stromal separation / significant increases / results indicated / provide models / physiological conditions / particularly vulnerable / matrix metalloproteinase / keratocyte death / inflammatory markers / inflammatory cells / inflammatory biomarkers / histopathological alterations / first used / detailed analyses / dependent increases / blood vessels / also observed / 7 min / Biophysics / Biochemistry / Medicine / Cell Biology / Physiology / Pharmacology / Chemical Sciences not elsewhere classified / Ecology / Immunology / Biological Sciences not elsewhere classified / Developmental Biology

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