The Ciliary Muscle and Zonules of Zinn Modulate Lens Intracellular Hydrostatic Pressure Through Transient Receptor Potential Vanilloid Channels.

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Title

The Ciliary Muscle and Zonules of Zinn Modulate Lens Intracellular Hydrostatic Pressure Through Transient Receptor Potential Vanilloid Channels.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Purpose: Lenses have an intracellular hydrostatic pressure gradient to drive fluid from central fiber cells to surface epithelial cells. Pressure is regulated by a feedback control system that relies on transient receptor potential vanilloid (TRPV)1 and TRPV4 channels. The ciliary muscle transmits tension to the lens through the zonules of Zinn. Here, we have examined if ciliary muscle tension influenced the lens intracellular hydrostatic pressure gradient.Methods: We measured the ciliary bod...

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Format

Research paper

Research format

Journal article

Date created

2019-10

Creator

Chen, Yadi / Gao, Junyuan / Li, Leping / Sellitto, Caterina / Mathias, Richard T / Donaldson, Paul J / White, Thomas W

URL

https://hdl.handle.net/2292/57058

Related subjects

Ligaments / Muscle, Smooth / Lens, Crystalline / Ciliary Body / Animals / Mice, Inbred C57BL / Mice, Knockout / Mice / Pilocarpine / Tropicamide / Mydriatics / Fluorescent Antibody Technique, Indirect / Muscle Contraction / Muscle Relaxation / Hydrostatic Pressure / TRPV Cation Channels / Phosphatidylinositol 3-Kinases / Science & Technology / Life Sciences & Biomedicine / Ophthalmology / lens epithelium / membrane channels / membrane transport / microcirculation / SYNERETIC RESPONSE / OPTICAL-PROPERTIES / ATP RELEASE / CIRCULATION / NA,K-ATPASE / ACTIVATION / EPITHELIUM / EXPRESSION / AGONISTS / RABBIT / 1116 Medical Physiology / Biomedical / Basic Science / 2.1 Biological and endogenous factors / 06 Biological Sciences / 11 Medical and Health Sciences

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