The Role of TGFβ1 and Macrophage Differentiation in MSU Crystal-Induced Inflammation

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Title

The Role of TGFβ1 and Macrophage Differentiation in MSU Crystal-Induced Inflammation

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Gout is a painful form of inflammatory arthritis that is caused by the deposition of monosodium urate (MSU) crystals in the joints. MSU crystals trigger a local inflammatory response initiated by resident macrophages followed by a large infiltration of leukocytes. The spontaneous resolution of acute gout is associated with the production of transforming growth factor β1 (TGFβ1). The overall objectives of this thesis were to investigate mechanisms that lead to TGFβ1 production and contribute t...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2014

Creator

Steiger, Stefanie

URL

https://figshare.com/articles/thesis/The_Role_of_TGF_1_and_Macrophage_Differentiation_in_MSU_Crys...

Related subjects

Medical biochemistry and metabolomics not elsewhere classified / TGFβ1 / Acute gouty inflammation / Macrophages / School: School of Biological Sciences / Medical Biochemistry and Metabolomics not elsewhere classified / Skeletal System and Disorders (incl. Arthritis) / Expanding Knowledge in the Medical and Health Sciences / Degree Discipline: Biomedical Science / Degree Level: Doctoral / Degree Name: Doctor of Philosophy

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