Composition, sequencing and ion mobility mass spectrometry of heparan sulfatelike octasaccharide isomers differing in glucuronic and iduronic acid content

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Title

Composition, sequencing and ion mobility mass spectrometry of heparan sulfatelike octasaccharide isomers differing in glucuronic and iduronic acid content

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Here we report ion mobility mass spectrometry (IMMS) separation and tandem mass spectrometry (MS2) sequencing methods used to analyze and differentiate six synthetically produced heparin/heparan sulfate (HS)-like octasaccharide (dp8) isomeric structures. These structures are isomeric with regard to either glucuronic acid (GlcA) or iduronic acid (IdoA) residues at various positions. IMMS analysis showed that a fully GlcA structure exhibited a more compact conformation, whereas the fully IdoA s...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2015

Creator

RL Miller / W Wei / Ralf Schwoerer / Olga Zubkova / Peter Tyler / JE Turnbull / JA Leary

URL

https://figshare.com/articles/journal_contribution/Composition_sequencing_and_ion_mobility_mass_s...

Related subjects

Biochemistry and cell biology not elsewhere classified / Analytical chemistry not elsewhere classified / Medicinal and biomolecular chemistry not elsewhere classified / Atomic, molecular and optical physics not elsewhere classified / Other physical sciences not elsewhere classified / glycosaminoglycan / heparan sulfate / IMMS / MS2 / electron detachment dissociation / arrival time distribution / glucuronic acid / iduronic-acid / Binding Sites / Glucuronic Acid / Heparitin Sulfate / Iduronic Acid / Isomerism / Polysaccharides / Sequence Analysis / Spectrometry, Mass, Electrospray Ionization / Science & Technology / Physical Sciences / Technology / Physics, Atomic, Molecular & Chemical / Spectroscopy / Physics / ELECTRON DETACHMENT DISSOCIATION / ANTITHROMBIN-BINDING SEQUENCE / GLYCOSAMINOGLYCAN TETRASACCHARIDES / DERMATAN SULFATE / RESIDUES / DOMAINS / GROWTH / OLIGOSACCHARIDES / CONFORMATION / DYNAMICS / Analytical Chemistry / Medicinal and Biomolecular Chemistry not elsewhere classified / Physical Sciences not elsewhere classified / Analytical Chemistry not elsewhere classified / Atomic, Molecular, Nuclear, Particle and Plasma Physics not elsewhere classified / Biochemistry and Cell Biology not elsewhere classified

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