Single-entity heparan sulfate glycomimetic clusters for therapeutic applications

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Title

Single-entity heparan sulfate glycomimetic clusters for therapeutic applications

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Heparan sulfate (HS) is a highly sulfated glycosaminoglycan with a variety of critical functions in cell signaling and regulation. HS oligosaccharides can mimic or interfere with HS functions in biological systems; however, their exploitation has been hindered by the complexity of their synthesis. Polyvalent displays of small specific HS structures on dendritic cores offer more accessible constructs with potential advantages as therapeutics, but the synthesis of single-entity HS polyvalent co...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2015

Creator

Peter Tyler / SE Guimond / JE Turnbull / Olga Zubkova

URL

https://figshare.com/articles/journal_contribution/Single-entity_heparan_sulfate_glycomimetic_clu...

Related subjects

Organic chemistry not elsewhere classified / Alzheimer's disease / dendrimers / glycomimetics / heparan sulfate / oligosaccharides / Basic Science / Aging / Acquired Cognitive Impairment / Dementia / Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) / Alzheimer's Disease / Brain Disorders / Neurodegenerative / Alzheimer’s disease / Alzheimer Disease / Amyloid Precursor Protein Secretases / Aspartic Acid Endopeptidases / Biomimetic Materials / Carbohydrate Conformation / Dose-Response Relationship, Drug / Heparitin Sulfate / Humans / Inhibitory Concentration 50 / Structure-Activity Relationship / Science & Technology / Physical Sciences / Chemistry, Multidisciplinary / Chemistry / ALZHEIMERS-DISEASE / BETA-SECRETASE / OLIGOSACCHARIDES / PROTEOGLYCANS / DENDRIMERS / LIBRARY / CANCER / Chemical Sciences / Organic Chemistry

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