Design and Synthesis of a Highly Simplified Pateamine Analogue

About this item

Title

Design and Synthesis of a Highly Simplified Pateamine Analogue

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Pateamine (1) is a natural product from the marine sponge Mycale hentscheli that exhibits potent anticancer properties, and has potential as an antiviral agent, and in preventing the muscle wasting disorder cachexia. This biological activity of pateamine is due to its ability to inhibit the eukaryotic initiation factor eIF4A, which leads to the formation of stress granules, the inhibition of protein synthesis, and ultimately cell death. Unfortunately, pateamine is obtained in very small amoun...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2016

Creator

Brown, Sarah

URL

https://figshare.com/articles/thesis/Design_and_Synthesis_of_a_Highly_Simplified_Pateamine_Analog...

Related subjects

Biochemistry and cell biology not elsewhere classified / Natural products and bioactive compounds / Organic chemical synthesis / Pateamine / Natural product / Analogue / School: School of Biological Sciences / Unit: Centre for Biodiscovery / Natural Products Chemistry / Biochemistry and Cell Biology not elsewhere classified / Organic Chemical Synthesis / Expanding Knowledge in the Biological Sciences / Expanding Knowledge in the Chemical Sciences / Degree Discipline: Biomedical Science / Degree Level: Masters / Degree Name: Master of Biomedical Science

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