Studies on the Synthesis of Marine Natural Product (-)-Zampanolide and its Analogues

About this item

Title

Studies on the Synthesis of Marine Natural Product (-)-Zampanolide and its Analogues

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

(-)-Zampanolide is a microtubule-stabilising marine natural product, with promise as a cancer drug candidate. The potential therapeutic application of zampanolide has fuelled worldwide interest in its total synthesis, but few analogue studies have been reported. Analogues afford the possibility of examining the structure-activity relationships with a view to optimising for potency and medicinal viability. This project seeks to devise a new route to zampanolide and generate a series of analogu...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2016

Creator

Wang, Jingjing

URL

https://figshare.com/articles/thesis/Studies_on_the_Synthesis_of_Marine_Natural_Product_-_-Zampan...

Related subjects

Organic chemical synthesis / Linchpin / Bestmann ylide / Asymmetric alkynylation / School: School of Chemical and Physical Sciences / Unit: Centre for Biodiscovery / Organic Chemical Synthesis / Expanding Knowledge in the Chemical Sciences / Degree Discipline: Chemistry / Degree Level: Doctoral / Degree Name: Doctor of Philosophy

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