Investigating the Specific Interactions Between Microtubule Stabilising Agents and β-Tubulin

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Title

Investigating the Specific Interactions Between Microtubule Stabilising Agents and β-Tubulin

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Microtubule stabilising agents are a class of cytotoxic compounds that cause mitotic arrest through inhibition of microtubule function. They specifically target β-tubulin subunits promoting tubulin polymerisation, which eventually leads to cell death. Members of this drug class include the cancer chemotherapeutics paclitaxel and ixabepilone. However, like many cytotoxic agents, tumour cells often develop multi-drug resistance phenotypes limiting the effectiveness of such compounds. This resul...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2017

Creator

Jones, Benjamin

URL

https://figshare.com/articles/thesis/Investigating_the_Specific_Interactions_Between_Microtubule_...

Related subjects

Biologically active molecules / Microtubles / Peloruside / Laulimalide / School: School of Biological Sciences / Biologically Active Molecules / Cancer and Related Disorders / Expanding Knowledge in the Chemical Sciences / Degree Discipline: Biologically Active Molecules / Degree Level: Masters / Degree Name: Master of Drug Discovery and Development

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