Trehalose amide glycolipids as Mincle ligands: Towards new vaccine adjuvants

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Title

Trehalose amide glycolipids as Mincle ligands: Towards new vaccine adjuvants

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

The development of new vaccines to respond to infectious diseases requires new vaccine adjuvants, which improve vaccine efficacy and shape the immune response. Trehalose glycolipids, consisting of α,α'-trehalose esterified at the 6- and 6'- positions with lipids, exhibit adjuvant activity by binding and activating Macrophage inducible C-type lectin (Mincle). However, the adjuvant activity of trehalose glycolipids could potentially be improved by substituting the ester linkages for more physio...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2018

Creator

Amy Lynch

URL

https://figshare.com/articles/thesis/Trehalose_amide_glycolipids_as_Mincle_ligands_Towards_new_va...

Related subjects

Organic chemical synthesis / Mincle / Glycolipids / Adjuvants / Amide / School: School of Chemical and Physical Sciences / Organic Chemical Synthesis / Expanding Knowledge in the Chemical Sciences / Degree Discipline: Chemistry / Degree Level: Masters / Degree Name: Master of Science

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