Towards Synthesis of Simplified Analogues of Pateamine A

About this item

Title

Towards Synthesis of Simplified Analogues of Pateamine A

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Pateamine A (22) is a natural product that was isolated from a marine sponge inhabiting the coast of New Zealand. It exhibits potent inhibition of protein synthesis and nonsense-mediated mRNA decay through binding with eIF4A isoforms. Due to the scarcity of pateamine A (22) in the natural source and the low yield of total synthesis of pateamine A, it is necessary to prepare structurally simplified analogues which would allow further research on structure-activity relationships (SAR) of pateam...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2020

Creator

Tao Xu

URL

https://figshare.com/articles/thesis/Towards_Synthesis_of_Simplified_Analogues_of_Pateamine_A/171...

Related subjects

Natural products and bioactive compounds / Organic chemical synthesis / pateamine / analogue / organic synthesis / natural products / School: School of Chemical and Physical Sciences / Unit: Centre for Biodiscovery / Organic Chemical Synthesis / Natural Products Chemistry / Expanding Knowledge in the Chemical Sciences / Degree Discipline: Chemistry / Degree Level: Doctoral / Degree Name: Doctor of Philosophy

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