About this item
- Title
- Towards Synthesis of Simplified Analogues of Pateamine A
- Content partner
- Victoria University of Wellington
- Collection
- Open Access Victoria University of Wellington
- Description
Pateamine A (22) is a natural product that was isolated from a marine sponge inhabiting the coast of New Zealand. It exhibits potent inhibition of protein synthesis and nonsense-mediated mRNA decay through binding with eIF4A isoforms. Due to the scarcity of pateamine A (22) in the natural source and the low yield of total synthesis of pateamine A, it is necessary to prepare structurally simplified analogues which would allow further research on structure-activity relationships (SAR) of pateam...
- Format
- Research paper
- Research format
- Scholarly text / Thesis
- Thesis level
- Doctoral
- Date created
- 2020
- Creator
- Tao Xu
- URL
- https://figshare.com/articles/thesis/Towards_Synthesis_of_Simplified_Analogues_of_Pateamine_A/171...
- Related subjects
- Natural products and bioactive compounds / Organic chemical synthesis / pateamine / analogue / organic synthesis / natural products / School: School of Chemical and Physical Sciences / Unit: Centre for Biodiscovery / Organic Chemical Synthesis / Natural Products Chemistry / Expanding Knowledge in the Chemical Sciences / Degree Discipline: Chemistry / Degree Level: Doctoral / Degree Name: Doctor of Philosophy
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Report this itemDigitalNZ brings together more than 30 million items from institutions so that they are easy to find and use. This information is the best information we could find on this item. This item was added on 13 December 2021, and updated 08 December 2024.
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