Synthesis of small molecule inhibitors for the treatment of disease

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Title

Synthesis of small molecule inhibitors for the treatment of disease

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Three aspects of the protecting-group-free (PGF) synthesis of small molecules have been described in this thesis. In the first part, the PGF azasugar synthesis methodology was applied to 2-deoxy-D-glucose with the intention of selectively forming the six-membered azasugar 5-epi-fagomine. Surprisingly, four products were formed in the key I2-mediated carbamate annulation step, with a pyrrolidine being the major product after optimisation. This was formed in 15% yield. A mechanism that explains...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2014

Creator

Corkran, Hilary Mary

URL

https://figshare.com/articles/thesis/Synthesis_of_small_molecule_inhibitors_for_the_treatment_of_...

Related subjects

Biologically active molecules / Medicinal and biomolecular chemistry not elsewhere classified / Organic chemical synthesis / Protecting-group-free / Synthesis / Drug-discovery / School: School of Chemical and Physical Sciences / Biologically Active Molecules / Medicinal and Biomolecular Chemistry not elsewhere classified / Organic Chemical Synthesis / Expanding Knowledge in the Chemical Sciences / Degree Discipline: Chemistry / Degree Level: Doctoral / Degree Name: Doctor of Philosophy

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