Development of a Hypoxia-Activated Trehalose Diester for the Treatment of Solid Tumours

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Title

Development of a Hypoxia-Activated Trehalose Diester for the Treatment of Solid Tumours

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

<b>The potential of bacterial cell wall components in the treatment of various cancers was initially realised in the late 1800s during pioneering work with Coley’s toxins. Since this preliminary work, efforts have been concentrated on the isolation and identification of bacterial components that lead to tumour regression. Trehalose dimycolates (TDMs) are compounds isolated from the M. tuberculosis cell wall and are known to activate macrophages to give a polarised Th1 immune response resultin...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2014

Creator

Foster, Amy Jane

URL

https://figshare.com/articles/thesis/Development_of_a_Hypoxia-Activated_Trehalose_Diester_for_the...

Related subjects

Medical biochemistry - carbohydrates / Medical biochemistry - lipids / Medical biochemistry and metabolomics not elsewhere classified / Organic chemical synthesis / Cancer / Prodrugs / TDEs / Trehalose diesters / School: School of Biological Sciences / Unit: School of Chemical and Physical Sciences / Organic Chemical Synthesis / Medical Biochemistry: Carbohydrates / Medical Biochemistry: Lipids / Medical Biochemistry and Metabolomics not elsewhere classified / Expanding Knowledge in the Chemical Sciences / Expanding Knowledge in the Biological Sciences / Expanding Knowledge in the Medical and Health Sciences / Degree Discipline: Chemistry / Degree Discipline: Biology / Degree Level: Masters / Degree Name: Master of Biomedical Science

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