Incorporation of a Nitric Oxide Donating Motif into Novel PC-PLC Inhibitors Provides Enhanced Anti-Proliferative Activity.

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Title

Incorporation of a Nitric Oxide Donating Motif into Novel PC-PLC Inhibitors Provides Enhanced Anti-Proliferative Activity.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Inhibition of phosphatidylcholine-specific phospholipase C (PC-PLC) has previously been shown to be a potential target for novel cancer therapeutics. One downstream consequence of PC-PLC activity is the activation of NF-κB, a nuclear transcription factor responsible for transcribing genes related to oncogenic traits, such as proliferation, angiogenesis, metastasis, and cancer cell survival. Another biological pathway linked to NF-κB is the exogenous delivery of nitric oxide (NO), which decrea...

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Format

Research paper

Research format

Journal article

Date created

2021-10-26

Creator

Rees, Shaun WP / Rees, Tayla A / Leung, Euphemia / Walker, Christopher S / Barker, David / Pilkington, Lisa I

URL

https://hdl.handle.net/2292/57990

Related subjects

2-morpholinobenzoic acids / DAF-FM / NF-κB / PC-PLC / anti-proliferative activity / nitric oxide donors / triple-negative breast cancer / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / NF-kappa B / NF-KAPPA-B / INDUCED CYCLOOXYGENASE-2 EXPRESSION / LIPOTEICHOIC ACID / SYNTHASE EXPRESSION / CELL-CYCLE / CANCER / ACTIVATION / INVOLVEMENT / INDUCTION / ROLES / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

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