Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep.

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Title

Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

BackgroundToll-like receptor (TLR) agonists are key immunomodulatory factors that can markedly ameliorate or exacerbate hypoxic-ischemic brain injury. We recently demonstrated that central infusion of the TLR7 agonist Gardiquimod (GDQ) following asphyxia was highly neuroprotective after 3 days but not 7 days of recovery. We hypothesize that this apparent transient neuroprotection is associated with modulation of seizure-genic processes and hemodynamic control.MethodsFetuses received sham asph...

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Format

Research paper

Research format

Journal article

Date created

2021-6-19

Creator

Cho, Kenta HT / Fraser, Mhoyra / Xu, Bing / Dean, Justin M / Gunn, Alistair J / Bennet, Laura

URL

https://hdl.handle.net/2292/58456

Related subjects

Animals / Sheep / Hypoxia-Ischemia, Brain / Seizures / Premature Birth / Imidazoles / Aminoquinolines / Electroencephalography / Fetal Therapies / Drug Evaluation, Preclinical / Pregnancy / Blood Pressure / Female / Toll-Like Receptor 7 / Toll-like receptors / cardiovascular / electrophysiology / fetal sheep / hypoxia–ischemia / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / hypoxia-ischemia / NECROSIS-FACTOR-ALPHA / HYPOXIA-ISCHEMIA / BRAIN-DAMAGE / ASPHYXIA / SEIZURES / INTERLEUKIN-10 / INFLAMMATION / ACTIVATION / INHIBITION / MECHANISMS / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

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