Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect.

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Title

Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect.

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The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

While delivery of chemotherapeutics to cancer cells by nanomedicines can improve therapeutic outcomes, many fail due to the low drug loading (DL), poor cellular uptake and endosomal entrapment. This study investigated the potential to overcome these limitations using pH-sensitive liposomes (PSL) empowered by the use of calcium acetate. An acidic dinitrobenzamide mustard prodrug SN25860 was used as a model drug, with non pH-sensitive liposomes (NPSL) as a reference. Calcium acetate as a remote...

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Format

Research paper

Research format

Journal article

Date created

2022-2-28

Creator

Yang, Mimi M / Yarragudi, Sasi Bhushan / Jamieson, Stephen MF / Tang, Mingtan / Wilson, William R / Wu, Zimei

URL

https://hdl.handle.net/2292/58724

Related subjects

Calcium acetate / Co-localization analysis / Cytosolic delivery / Endosomal entrapment / Proton sponge effect / Remote drug loading / pH-sensitive liposomes / 1115 Pharmacology and Pharmaceutical Sciences

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