A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors

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Title

A transcription regulatory network within the ACE2 locus may promote a pro-viral environment for SARS-CoV-2 by modulating expression of host factors

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The University of Auckland Library

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ResearchSpace@Auckland

Description

AbstractIntroductionA novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was recently identified as the pathogen responsible for the COVID-19 outbreak. SARS-CoV-2 triggers severe pneumonia, which leads to acute respiratory distress syndrome and death in severe cases. As reported, SARS-CoV-2 is 80% genetically identical to the 2003 SARS-CoV virus. Angiotensin-converting enzyme 2 (ACE2) has been identified as the main receptor for entry of both SARS-CoV and SARS-CoV-2 into human...

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Format

Research paper

Research format

Journal article

Date created

2020-04-15

Creator

Fadason, Tayaza / Gokuladhas, Sreemol / Golovina, Evgeniia / Ho, Daniel / Farrow, Sophie / Nyaga, Denis / Pan, Hong / Karnani, Neerja / Wong, Conroy / Cooper, Antony / Schierding, William / O’Sullivan, Justin M

URL

https://hdl.handle.net/2292/58870

Related subjects

Biodefense / Pneumonia / Prevention / Pneumonia & Influenza / Lung / Infectious Diseases / Emerging Infectious Diseases / Vaccine Related / Genetics / 2.1 Biological and endogenous factors / Respiratory / Infection

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