Positive Selection or Free to Vary? Assessing the Functional Significance of Sequence Change Using Molecular Dynamics.

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Title

Positive Selection or Free to Vary? Assessing the Functional Significance of Sequence Change Using Molecular Dynamics.

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The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Evolutionary arms races between pathogens and their hosts may be manifested as selection for rapid evolutionary change of key genes, and are sometimes detectable through sequence-level analyses. In the case of protein-coding genes, such analyses frequently predict that specific codons are under positive selection. However, detecting positive selection can be non-trivial, and false positive predictions are a common concern in such analyses. It is therefore helpful to place such predictions wit...

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Format

Research paper

Research format

Journal article

Date created

2016-01

Creator

Allison, Jane R / Lechner, Marcus / Hoeppner, Marc P / Poole, Anthony M

URL

https://hdl.handle.net/2292/59182

Related subjects

Tombusvirus / Lycopersicon esculentum / Viral Proteins / RNA / Crystallography, X-Ray / Sequence Alignment / Phylogeny / Plant Diseases / Gene Expression / Binding Sites / Amino Acid Sequence / Protein Structure, Secondary / Protein Binding / Sequence Homology, Amino Acid / Mutation / Molecular Sequence Data / Protein Interaction Domains and Motifs / Protein Multimerization / Selection, Genetic / Molecular Dynamics Simulation / Immune Evasion / Genetics / Prevention / 1.1 Normal biological development and functioning / Generic health relevance / Infection / Science & Technology / Multidisciplinary Sciences / Science & Technology - Other Topics / RNA SILENCING SUPPRESSOR / MAXIMUM-LIKELIHOOD / BRANCH-SITE / VIRUS / EVOLUTION / GENES / DROSOPHILA / INTERFERENCE / SUBSTITUTION / RECOGNITION / 0604 Genetics

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