Understanding enzymatic mechanism and allostery using macromolecular rate theory

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Title

Understanding enzymatic mechanism and allostery using macromolecular rate theory

Content partner

University of Waikato

Collection

ResearchCommons@Waikato

Description

Intricate systems of regulation at many levels act to control enzyme rates to tune metabolism across biosynthetic pathways. Allostery is a ubiquitous regulatory mechanism for feedback and regulation of enzymes in biosynthetic pathways. ATP-phosphoribosyltransferase from Mycobacterium tuberculosis (mtuATP-PRT) catalyses the first committed step in de novo histidine biosynthesis, and allosteric product inhibition of ATP-PRT by L-His is key to regulating metabolic flux in this pathway. mtuATP-PR...

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Format

Research paper

Research format

Thesis

Thesis level

Doctoral

Date created

2022

Creator

Grout, Emily Katherine

URL

https://hdl.handle.net/10289/14987

Related subjects

Biochemistry / Enzyme / Kinetics / Allostery / Thermodynamics / Macromolecular rate theory / MMRT / Crystallography / Molecular dynamics / Phylogenetics / Allosteric enzymes -- Mathematical models / Allosteric regulation -- Mathematical models / Enzyme kinetics -- Mathematical models / Enzymes -- Regulation -- Mathematical models / Enzymes -- Biotechnology -- Mathematical models / Enzymes -- Analysis -- Mathematical models / Heat

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