Research paper

Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

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Title
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Content partner
University of Canterbury Library
Collection
UC Research Repository
Description

Background: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore this overlap and heterogeneity as it is determined by the combined effects of genetic variation and the environment. In this study, we aim to identify shared blood DNAm differences between controls and people with Alzheimer’s disease, amyotrophic l...

Format
Research paper
Research format
Journal article
Date created
2021
Creator
Nabais MF / Laws SM / Lin T / Vallerga CL / Armstrong NJ / Blair IP / Kwok JB / Mather KA / Mellick GD / Sachdev PS / Wallace L / Henders AK / Zwamborn RAJ / Hop PJ / Lunnon K / Pishva E / Roubroeks JAY / Soininen H / Tsolaki M / Mecocci P / Lovestone S / Kłoszewska I / Vellas B / Furlong S / Garton FC / Henderson RD / Mathers S / McCombe PA / Needham M / Ngo ST / Nicholson G / Pamphlett R / Rowe DB / Steyn FJ / Williams KL / Anderson TJ / Bentley SR / Fowder J / Gratten J / Halliday G / Hickie IB / Kennedy M / Lewis SJG / Montgomery GW / Pearson J / Pitcher TL / Silburn P / Zhang F / Visscher PM / Yang J / Stevenson AJ / Hillary RF / Marioni RE / Harris SE / Deary IJ / Jones AR / Shatunov A / Iacoangeli A / van Rheenen W / van den Berg LH / Shaw PJ / Shaw CE / Morrison KE / Al-Chalabi A / Veldink JH / Hannon E / Mill J / Wray NR / McRae AF / Dalrymple-Alford, John
URL
https://hdl.handle.net/10092/102198
Related subjects
neurodegenerative disorders / DNA methylation / Mixed-linear models / Methylation profile score / Out-of-sample classification / inflammatory markers / Biomedical and clinical sciences / Neurosciences / Neurology and neuromuscular diseases / Biological sciences / Genetics / Epigenetics (incl. genome methylation and epigenomics)

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