Research paper
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
About this item
- Title
- Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
- Content partner
- University of Canterbury Library
- Collection
- UC Research Repository
- Description
Background: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore this overlap and heterogeneity as it is determined by the combined effects of genetic variation and the environment. In this study, we aim to identify shared blood DNAm differences between controls and people with Alzheimer’s disease, amyotrophic l...
- Format
- Research paper
- Research format
- Journal article
- Date created
- 2021
- Creator
- Nabais MF / Laws SM / Lin T / Vallerga CL / Armstrong NJ / Blair IP / Kwok JB / Mather KA / Mellick GD / Sachdev PS / Wallace L / Henders AK / Zwamborn RAJ / Hop PJ / Lunnon K / Pishva E / Roubroeks JAY / Soininen H / Tsolaki M / Mecocci P / Lovestone S / Kłoszewska I / Vellas B / Furlong S / Garton FC / Henderson RD / Mathers S / McCombe PA / Needham M / Ngo ST / Nicholson G / Pamphlett R / Rowe DB / Steyn FJ / Williams KL / Anderson TJ / Bentley SR / Fowder J / Gratten J / Halliday G / Hickie IB / Kennedy M / Lewis SJG / Montgomery GW / Pearson J / Pitcher TL / Silburn P / Zhang F / Visscher PM / Yang J / Stevenson AJ / Hillary RF / Marioni RE / Harris SE / Deary IJ / Jones AR / Shatunov A / Iacoangeli A / van Rheenen W / van den Berg LH / Shaw PJ / Shaw CE / Morrison KE / Al-Chalabi A / Veldink JH / Hannon E / Mill J / Wray NR / McRae AF / Dalrymple-Alford, John
- URL
- https://hdl.handle.net/10092/102198
- Related subjects
- neurodegenerative disorders / DNA methylation / Mixed-linear models / Methylation profile score / Out-of-sample classification / inflammatory markers / Biomedical and clinical sciences / Neurosciences / Neurology and neuromuscular diseases / Biological sciences / Genetics / Epigenetics (incl. genome methylation and epigenomics)
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© The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
You can learn more about the rights status of this item at: http://hdl.handle.net/10092/17651
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