HOspitalised Pneumonia Extended (HOPE) Study to reduce the long-term effects of childhood pneumonia: protocol for a multicentre, double-blind, parallel, superiority randomised controlled trial.

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Title

HOspitalised Pneumonia Extended (HOPE) Study to reduce the long-term effects of childhood pneumonia: protocol for a multicentre, double-blind, parallel, superiority randomised controlled trial.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

IntroductionEarly childhood pneumonia is a common problem globally with long-term complications that include bronchiectasis and chronic obstructive pulmonary disease. It is biologically plausible that these long-term effects may be minimised in young children at increased risk of such sequelae if any residual lower airway infection and inflammation in their developing lungs can be treated successfully by longer antibiotic courses. In contrast, shortened antibiotic treatments are being promote...

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Format

Research paper

Research format

Journal article

Date created

2019-04-24

Creator

Chang, Anne B / Fong, Siew Moy / Yeo, Tsin Wen / Ware, Robert S / McCallum, Gabrielle B / Nathan, Anna M / Ooi, Mong H / de Bruyne, Jessie / Byrnes, Catherine A / Lee, Bilawara / Nachiappan, Nachal / Saari, Noorazlina / Torzillo, Paul / Smith-Vaughan, Heidi / Morris, Peter S / Upham, John W / Grimwood, Keith

URL

https://hdl.handle.net/2292/59742

Related subjects

Humans / Pneumonia / Anti-Bacterial Agents / Treatment Outcome / Hospitalization / Incidence / Retrospective Studies / Follow-Up Studies / Double-Blind Method / Time Factors / Child, Preschool / Infant / Malaysia / Australia / New Zealand / Female / Male / children / clinical trials / Clinical Research / Clinical Trials and Supportive Activities / Lung / Infectious Diseases / Antimicrobial Resistance / Pneumonia & Influenza / Prevention / Pediatric / 6.1 Pharmaceuticals / Infection / Respiratory / Science & Technology / Life Sciences & Biomedicine / Medicine, General & Internal / General & Internal Medicine / COMMUNITY-ACQUIRED PNEUMONIA / COURSE ANTIBIOTIC-THERAPY / SUPPURATIVE LUNG-DISEASE / ACUTE OTITIS-MEDIA / AGED 2-59 MONTHS / CHRONIC COUGH / INDIGENOUS CHILDREN / ANTIMICROBIAL TREATMENT / BRONCHIECTASIS / AMOXICILLIN / 1117 Public Health and Health Services / 1103 Clinical Sciences / Clinical / Clinical Medicine and Science / 1199 Other Medical and Health Sciences

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