The effect of CK2-mediated hyperphosphorylation of Ryanodine receptor type II (RyR2) on Ca2+ leak in mice cardiomyocytes

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Title

The effect of CK2-mediated hyperphosphorylation of Ryanodine receptor type II (RyR2) on Ca2+ leak in mice cardiomyocytes

Content partner

University of Otago

Collection

Otago University Research Archive

Description

Background: Nearly 18 million people die from cardiovascular disease (CVD) each year according to the World Health Organisation. One of the outcomes of CVD is the development of cardiac arrhythmias. A mechanism through which arrhythmias occur is due to abnormal calcium (Ca2+) signalling via the Ryanodine Receptor Type II (RyR2). Several kinases are known to alter the activity of RyR2, with the consensus being that hyperphosphorylation leads to abnormal Ca2+ release and arrhythmia. Within the ...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2022

Creator

Hintz, Madyson

URL

https://hdl.handle.net/10523/14212

Related subjects

New Zealand / Calcium / Cardiomyocytes / Cardiac / Arrhythmias

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