Hyposmotic stress causes ATP release in a discrete zone within the outer cortex of rat lens.

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Title

Hyposmotic stress causes ATP release in a discrete zone within the outer cortex of rat lens.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

PurposePurinergic signaling pathways activated by extracellular ATP have been implicated in the regulation of lens volume and transparency. In this study, we investigated the location of ATP release from whole rat lenses and the mechanism by which osmotic challenge alters such ATP release.MethodsThree-week-old rat lenses were cultured for 1 h in isotonic artificial aqueous humor (AAH) with no extracellular Ca2+, hypotonic AAH, or hypertonic AAH. The hypotonic AAH-treated lenses were also cult...

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Format

Research paper

Research format

Journal article

Date created

2022-01

Creator

Suzuki-Kerr, Haruna / Walker, Kerry L / Han, Min-Hi / Lim, Julie C / Donaldson, Paul J

URL

https://hdl.handle.net/2292/62331

Related subjects

Animals / Rats / Probenecid / Flufenamic Acid / Carbenoxolone / Dextrans / Connexins / Adenosine Triphosphate / Eye Disease and Disorders of Vision / 1113 Opthalmology and Optometry

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