Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens.

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Title

Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

The transient receptor protein vanilloid channels, TRPV1 and TRPV4, have recently been shown to be mechanosensors in the ocular lens that act to transduce physical changes in lens volume and internal hydrostatic pressure into the activation of signalling pathways in lens epithelial cells. These pathways in turn regulate ion and water transport to ensure that the optical properties of the lens remain constant. Despite the functional evidence that implicate the roles of TRPV1 and TRPV4 in the l...

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Format

Research paper

Research format

Journal article

Date created

2019-09

Creator

Nakazawa, Yosuke / Donaldson, Paul J / Petrova, Rosica S

URL

https://hdl.handle.net/2292/62485

Related subjects

Lens, Crystalline / Cell Membrane / Cytoplasm / Animals / Mice / Eye Proteins / Immunohistochemistry / Models, Animal / TRPV Cation Channels / Lens / Lens development / Transient receptor channel expression from the vanilloid subfamily / Eye Disease and Disorders of Vision / 1.1 Normal biological development and functioning / 1 Underpinning research / Science & Technology / Life Sciences & Biomedicine / Ophthalmology / Transient receptor channel expression from the / vanilloid subfamily / INTRACELLULAR HYDROSTATIC-PRESSURE / DIFFERENTIAL EXPRESSION / FIBER CELLS / CHANNELS / TRANSPORTERS / ACTIVATION / IDENTIFICATION / TRAFFICKING / ROLES / 0601 Biochemistry and Cell Biology / Biomedical / Basic Science / 1101 Medical Biochemistry and Metabolomics / 1109 Neurosciences / 1113 Opthalmology and Optometry

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