Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging.

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Title

Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Glutathione (GSH) is the archetypal antioxidant, and plays a central role in the protection of the ocular lens from cataract formation. High levels of GSH are maintained in the transparent lens, but with advancing age, GSH levels fall in the lens nucleus relative to outer cortical cells, thereby exposing the nucleus of the lens to the damaging effects of oxygen radicals, which ultimately leads to age-related nuclear (ARN) cataract. Under normal conditions, GSH also forms endogenous conjugates...

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Format

Research paper

Research format

Journal article

Date created

2017-01

Creator

Nye-Wood, Mitchell G / Spraggins, Jeffrey M / Caprioli, Richard M / Schey, Kevin L / Donaldson, Paul J / Grey, Angus C

URL

https://hdl.handle.net/2292/62484

Related subjects

Lens, Crystalline / Animals / Cattle / Cataract / Disease Models, Animal / Glutathione / Crystallins / Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Oxidative Stress / Tissue Distribution / Aging / Tandem Mass Spectrometry / Metabolomics / FTICR mass spectrometry / HDR mass spectrometry / Lens / MALDI imaging / Eye Disease and Disorders of Vision / 1.1 Normal biological development and functioning / 1 Underpinning research / Science & Technology / Life Sciences & Biomedicine / Ophthalmology / IMAGING MASS-SPECTROMETRY / FIBER CELL-DIFFERENTIATION / OXIDATIVE STRESS DEFENSE / AGE-RELATED-CHANGES / HYPERBARIC-OXYGEN / NUCLEAR CATARACT / LIPID DISTRIBUTION / MIXED DISULFIDES / ALPHA-CRYSTALLIN / OCULAR LENS / 0601 Biochemistry and Cell Biology / Biomedical / Basic Science / 1101 Medical Biochemistry and Metabolomics / 1109 Neurosciences / 1113 Opthalmology and Optometry

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