Changes to Zonular Tension Alters the Subcellular Distribution of AQP5 in Regions of Influx and Efflux of Water in the Rat Lens.

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Title

Changes to Zonular Tension Alters the Subcellular Distribution of AQP5 in Regions of Influx and Efflux of Water in the Rat Lens.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

PurposeThe lens uses circulating fluxes of ions and water that enter the lens at both poles and exit at the equator to maintain its optical properties. We have mapped the subcellular distribution of the lens aquaporins (AQP0, AQP1, and AQP5) in these water influx and efflux zones and investigated how their membrane location is affected by changes in tension applied to the lens by the zonules.MethodsImmunohistochemistry using AQP antibodies was performed on axial sections obtained from rat len...

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Format

Research paper

Research format

Journal article

Date created

2020-09

Creator

Petrova, Rosica S / Bavana, Nandini / Zhao, Rusin / Schey, Kevin L / Donaldson, Paul J

URL

https://hdl.handle.net/2292/62456

Related subjects

Lens, Crystalline / Animals / Rats / Rats, Wistar / Water / Organ Culture Techniques / Immunohistochemistry / Models, Animal / Biological Transport / Aquaporin 5 / Eye Disease and Disorders of Vision / Science & Technology / Life Sciences & Biomedicine / Ophthalmology / lens / water transport / AQP0 / AQP1 / AQP5 / zonular tension / INTRACELLULAR HYDROSTATIC-PRESSURE / AQUAPORIN-0 INTERACTS / EXPRESSION / PERMEABILITY / FILENSIN / RECEPTOR / CHANNEL / ROLES / LOCALIZATION / ORGANIZATION / 1113 Opthalmology and Optometry / 06 Biological Sciences / 11 Medical and Health Sciences

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