Characterisation of Glutathione Export from Human Donor Lenses.

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Title

Characterisation of Glutathione Export from Human Donor Lenses.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

PurposeTo investigate whether human donor lenses are capable of exporting reduced glutathione.MethodsHuman lenses of varying ages were cultured in artificial aqueous humor for 1 hour under hypoxic conditions to mimic the physiologic environment and reduced glutathione (GSH) and oxidized glutathione (GSSG) levels measured in the media and in the lens.ResultsHuman donor lenses released both GSH and GSSG into the media. Donor lenses cultured in the presence of acivicin, a γ-glutamyltranspeptidas...

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Format

Research paper

Research format

Journal article

Date created

2020-07

Creator

Li, Bo / Kim, Ji-Youn / Martis, Renita M / Donaldson, Paul J / Lim, Julie C

URL

https://hdl.handle.net/2292/62459

Related subjects

Lens, Crystalline / Humans / Glutathione / Glutathione Disulfide / Biological Transport / Oxidative Stress / lens / multidrug resistance-associated proteins / Eye Disease and Disorders of Vision / Science & Technology / Life Sciences & Biomedicine / Ophthalmology / REDUCED GLUTATHIONE / AQUEOUS-HUMOR / RABBIT LENS / ASCORBIC-ACID / FUNCTIONAL-CHARACTERIZATION / MOLECULAR CHARACTERIZATION / OXIDIZED GLUTATHIONE / INDUCED CATARACT / BARRIER FUNCTION / TRANSPORT / 0903 Biomedical Engineering / 1113 Opthalmology and Optometry

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