Anakinra Pilot - a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants.

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Title

Anakinra Pilot - a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

BackgroundBronchopulmonary dysplasia (BPD), its complication pulmonary hypertension (BPD-PH) and preterm brain and gut injury lead to significant morbidity and mortality in infants born extremely prematurely. There is extensive evidence that the pro-inflammatory cytokine interleukin 1 (IL-1) plays a key role in the pathophysiology of these illnesses. Two decades of clinical use in paediatric and adult medicine have established an excellent safety and efficacy record for IL-1 blockade with IL-...

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Format

Research paper

Research format

Journal article

Date created

2022-01

Creator

Green, Elys A / Metz, David / Galinsky, Robert / Atkinson, Rebecka / Skuza, Elizbeth M / Clark, Megan / Gunn, Alistair J / Kirkpatrick, Carl M / Hunt, Rod W / Berger, Philip J / Nold-Petry, Claudia A / Nold, Marcel F

URL

https://hdl.handle.net/2292/62598

Related subjects

Humans / Bronchopulmonary Dysplasia / Receptors, Interleukin-1 / Interleukin-1 / Feasibility Studies / Adult / Child / Infant / Infant, Newborn / Interleukin 1 Receptor Antagonist Protein / Infant, Extremely Premature / anti-inflammatory therapy / clinical trial / drug repurposing / inflammation / interleukin 1 receptor antagonist / preterm infant / protocol anakinra pilot / translational research / Neonatal Respiratory Distress / Infant Mortality / Perinatal Period - Conditions Originating in Perinatal Period / Clinical Trials and Supportive Activities / Preterm, Low Birth Weight and Health of the Newborn / Patient Safety / Pediatric / Clinical Research / Lung / Reproductive health and childbirth / 3 Good Health and Well Being / 1107 Immunology / 1108 Medical Microbiology

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