Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues.

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Title

Identification, Expression, and Roles of the Cystine/Glutamate Antiporter in Ocular Tissues.

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

The cystine/glutamate antiporter (system x c -) is composed of a heavy chain subunit 4F2hc linked by a disulphide bond to a light chain xCT, which exchanges extracellular cystine, the disulphide form of the amino acid cysteine, for intracellular glutamate. In vitro research in the brain, kidney, and liver have shown this antiporter to play a role in minimising oxidative stress by providing a source of intracellular cysteine for the synthesis of the antioxidant glutathione. In vivo studies usi...

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Format

Research paper

Research format

Journal article

Date created

2020-01

Creator

Martis, Renita M / Knight, Luis J / Donaldson, Paul J / Lim, Julie C

URL

https://hdl.handle.net/2292/62527

Related subjects

Eye / Animals / Humans / Cystine / Cysteine / Glutamic Acid / Glutathione / Amino Acid Transport System y+ / Antiporters / Oxidation-Reduction / Oxidative Stress / Vision, Ocular / Eye Disease and Disorders of Vision / Rare Diseases / Neurosciences / Science & Technology / Life Sciences & Biomedicine / Cell Biology / AMINO-ACID TRANSPORTERS / SYSTEM X(C)(-) / REDOX STATE / L-CYSTINE / REGIONAL DIFFERENCES / GLIAL-CELLS / GLUTAMATE / INDUCTION / 11 Medical and Health Sciences

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