Regulation of the Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens.

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Title

Regulation of the Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Lens water transport generates a hydrostatic pressure gradient that is regulated by a dual-feedback system that utilizes the mechanosensitive transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, to sense changes in mechanical tension and extracellular osmolarity. Here, we investigate whether the modulation of TRPV1 or TRPV4 activity dynamically affects their membrane trafficking. Mouse lenses were incubated in either pilocarpine or tropicamide to alter zonular tension, exp...

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Format

Research paper

Research format

Journal article

Date created

2021-11

Creator

Nakazawa, Yosuke / Petrova, Rosica S / Sugiyama, Yuki / Nagai, Noriaki / Tamura, Hiroomi / Donaldson, Paul J

URL

https://hdl.handle.net/2292/62612

Related subjects

Lens, Crystalline / Cell Membrane / Animals / Mice / Capsaicin / Gene Expression Regulation / Biological Transport / Osmotic Pressure / Hydrostatic Pressure / TRPV Cation Channels / TRPV1/4 / cell volume / lens / mechanosensors / osmotic stress / zonular tension / Pain Research / Chronic Pain / 1.1 Normal biological development and functioning / 1 Underpinning research / Science & Technology / Life Sciences & Biomedicine / Physical Sciences / Biochemistry & Molecular Biology / Chemistry, Multidisciplinary / Chemistry / TRPV1 / 4 / INTRACELLULAR HYDROSTATIC-PRESSURE / RECEPTOR / CELLS / 0399 Other Chemical Sciences / 0604 Genetics / 0699 Other Biological Sciences

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