Chai-Qin-Cheng-Qi Decoction and Carbachol Improve Intestinal Motility by Regulating Protein Kinase C-Mediated Ca2+ Release in Colonic Smooth Muscle Cells in Rats with Acute Necrotising Pancreatitis.

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Title

Chai-Qin-Cheng-Qi Decoction and Carbachol Improve Intestinal Motility by Regulating Protein Kinase C-Mediated Ca2+ Release in Colonic Smooth Muscle Cells in Rats with Acute Necrotising Pancreatitis.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Chai-Qin-Cheng-Qi decoction (CQCQD) improves intestinal motility in acute pancreatitis (AP), but the mechanism(s) require elucidation. We investigated the effects of CQCQD and carbachol, a prokinetic agent, on colonic smooth muscle cells (SMCs) in L-arginine-induced necrotising AP model in rats. In treatment groups, intragastric CQCQD (20 g/kg, 2 hourly × 3 doses) or intraperitoneal carbachol (60 μg/kg) was given 24 hours after induction of AP. Both CQCQD and carbachol decreased the severity ...

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Format

Research paper

Research format

Conference item

Date created

2017-01

Creator

Zhang, Chen-Long / Lin, Zi-Qi / Luo, Rui-Jie / Zhang, Xiao-Xin / Guo, Jia / Wu, Wei / Shi, Na / Deng, Li-Hui / Chen, Wei-Wei / Zhang, Xiao-Ying / Bharucha, Shameena / Huang, Wei / Sutton, Robert / Windsor, John A / Xue, Ping / Xia, Qing

URL

https://hdl.handle.net/2292/62675

Related subjects

Digestive Diseases / 2.1 Biological and endogenous factors / 2 Aetiology / Oral and gastrointestinal / Science & Technology / Life Sciences & Biomedicine / Gastroenterology & Hepatology / 1115 Pharmacology and Pharmaceutical Sciences / Biomedical / Basic Science / 1104 Complementary and Alternative Medicine

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