Synthesis of Novel C/D Ring Modified Bile Acids

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Title

Synthesis of Novel C/D Ring Modified Bile Acids

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Bile acid receptors have been identified as important targets for the development of new therapeutics to treat various metabolic and inflammatory diseases. The synthesis of new bile acid analogues can help elucidate structure–activity relationships and define compounds that activate these receptors selectively. Towards this, access to large quantities of a chenodeoxycholic acid derivative bearing a C-12 methyl and a C-13 to C-14 double bond provided an interesting scaffold to investigate the ...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2022

Creator

RA Landaeta Aponte / Andreas Luxenburger / Scott Cameron / A Weymouth-Wilson / Richard Furneaux / Lawrence Harris / Benjamin Compton

URL

https://figshare.com/articles/journal_contribution/Synthesis_of_Novel_C_D_Ring_Modified_Bile_Acid...

Related subjects

Medicinal and biomolecular chemistry not elsewhere classified / Organic chemistry not elsewhere classified / Theoretical and computational chemistry not elsewhere classified / bile acid / zinc carbenoids / cyclopropane / rearrangement / drug discovery / Bile Acids and Salts / Chenodeoxycholic Acid / Oxidation-Reduction / Steroids / Structure-Activity Relationship / Digestive Diseases / Organic Chemistry / Medicinal and Biomolecular Chemistry not elsewhere classified / Theoretical and Computational Chemistry not elsewhere classified

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