Cell reprogramming for oligodendrocytes: A review of protocols and their applications to disease modeling and cell-based remyelination therapies.

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Title

Cell reprogramming for oligodendrocytes: A review of protocols and their applications to disease modeling and cell-based remyelination therapies.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

Oligodendrocytes are a type of glial cells that produce a lipid-rich membrane called myelin. Myelin assembles into a sheath and lines neuronal axons in the brain and spinal cord to insulate them. This not only increases the speed and efficiency of nerve signal transduction but also protects the axons from damage and degradation, which could trigger neuronal cell death. Demyelination, which is caused by a loss of myelin and oligodendrocytes, is a prominent feature of many neurological conditio...

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Format

Research paper

Research format

Journal article

Date created

2023-02

Creator

McCaughey-Chapman, Amy / Connor, Bronwen

URL

https://hdl.handle.net/2292/63128

Related subjects

cell-based remyelination therapy / demyelination / disease modeling / induced pluripotent stem cells / multiple sclerosis / oligodendrocyte / oligodendrocyte precursor cells / organoids / reprogramming / spinal cord injury / 1109 Neurosciences / 1701 Psychology

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