Metabolomics and a Breath Sensor Identify Acetone as a Biomarker for Heart Failure.

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Title

Metabolomics and a Breath Sensor Identify Acetone as a Biomarker for Heart Failure.

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The University of Auckland Library

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ResearchSpace@Auckland

Description

BackgroundMulti-omics delivers more biological insight than targeted investigations. We applied multi-omics to patients with heart failure with reduced ejection fraction (HFrEF).Methods46 patients with HFrEF and 20 controls underwent metabolomic profiling, including liquid/gas chromatography mass spectrometry (LC-MS/GC-MS) and solid-phase microextraction (SPME) volatilomics in plasma and urine. HFrEF was defined using left ventricular global longitudinal strain, ejection fraction and NTproBNP...

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Format

Research paper

Research format

Journal article

Date created

2022-12

Creator

Gladding, Patrick A / Cooper, Maxine / Young, Renee / Loader, Suzanne / Smith, Kevin / Zarate, Erica / Green, Saras / Villas Boas, Silas G / Shepherd, Phillip / Kakadiya, Purvi / Thorstensen, Eric / Keven, Christine / Coe, Margaret / Jüllig, Mia / Zhang, Edmond / Schelegel, Todd T

URL

https://hdl.handle.net/2292/63376

Related subjects

Humans / Acetone / Stroke Volume / Heart Failure / Metabolomics / Biomarkers / heart failure with reduced ejection fraction / Clinical Research / Heart Disease / Cardiovascular / 0601 Biochemistry and Cell Biology

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