BRAF Alteration in Central and Peripheral Nervous System Tumors.

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Title

BRAF Alteration in Central and Peripheral Nervous System Tumors.

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

BRAF (alternately referred to as v-raf murine sarcoma viral oncogene homolog B1) is a proto-oncogene involved in the mitogen-activated protein kinase (MAPK) pathway. BRAF alterations are most commonly missense mutations or aberrant fusions. These mutations are observed in numerous primary central nervous system tumors as well as metastases. This review discusses the prevalence of BRAF alteration within select notable CNS tumors, and their prognostic associations. Included are some novel entit...

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Format

Research paper

Research format

Journal article

Date created

2020-01

Creator

Srinivasa, Komal / Cross, Kevin A / Dahiya, Sonika

URL

https://hdl.handle.net/2292/63339

Related subjects

BRAF / CNS / PNS / diagnosis / prognosis / targeted-therapy / tumor / Genetics / Cancer / Neurosciences / 1112 Oncology and Carcinogenesis

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