Screening for small molecule modulators of trypanosoma brucei HSP70 chaperone activity based upon alcyonarian coral-derived natural products

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Title

Screening for small molecule modulators of trypanosoma brucei HSP70 chaperone activity based upon alcyonarian coral-derived natural products

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

The Trypanosoma brucei Hsp70/J-protein machinery plays an essential role in survival, differentiation, and pathogenesis of the protozoan parasite, and is an emerging target against African Trypanosomiasis. This study evaluated a set of small molecules, inspired by the malonganenones and nuttingins, as modulators of the chaperone activity of the cytosolic heat inducible T. brucei Hsp70 and constitutive TbHsp70.4 proteins. The compounds were assessed for cytotoxicity on both the bloodstream for...

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Format

Research paper

Research format

Scholarly text / Journal article

Date created

2020

Creator

SK Andreassend / SJ Bentley / GL Blatch / A Boshoff / Robert Keyzers

URL

https://figshare.com/articles/journal_contribution/Screening_for_small_molecule_modulators_of_try...

Related subjects

Pharmacology and pharmaceutical sciences not elsewhere classified / Physical chemistry not elsewhere classified / anti-parasitic / heat shock protein / malonganenone / SAR / African Trypanosomiasis / Animals / Anthozoa / Biological Products / HSP70 Heat-Shock Proteins / Structure-Activity Relationship / Trypanosoma brucei brucei / Trypanosomiasis, African / Biotechnology / Infectious Diseases / Rare Diseases / Vector-Borne Diseases / Infection / Good Health and Well Being / Medicinal & Biomolecular Chemistry / Pharmacology and Pharmaceutical Sciences not elsewhere classified / Physical Chemistry not elsewhere classified

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