In Silico Modeling for Ex Vivo Placental Transfer of Morphine.

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Title

In Silico Modeling for Ex Vivo Placental Transfer of Morphine.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Morphine may be administered in pregnant women as an analgesic agent. The transplacental pharmacokinetics (PK) of morphine varies during pregnancy because of physiological and metabolic changes. In this work, we use a multi-compartment model to simulate ex vivo human placental transfer studies of morphine. The computational model is based on a recently published model for metformin with both passive and active transport kinetics. Modifications were made to incorporate morphine-specific transf...

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Format

Research paper

Research format

Journal article

Date created

2022-09

Creator

Ho, Harvey / Zhang, Shengjie / Kurosawa, Ken / Chiba, Koji

URL

https://hdl.handle.net/2292/63678

Related subjects

Placenta / Humans / Morphine / Pregnancy / Maternal-Fetal Exchange / Models, Biological / Computer Simulation / Female / model / opioid / pharmacokinetics / pregnant woman / Pediatric / Reproductive health and childbirth / 3 Good Health and Well Being / 1115 Pharmacology and Pharmaceutical Sciences

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