RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors.

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Title

RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors.

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The University of Auckland Library

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Description

Background and purposeReceptor activity-modifying proteins (RAMPs) and melanocortin receptor accessory proteins (MRAPs) modulate expression and signalling of calcitonin and melanocortin GPCRs. Interactions with other GPCRs have also been reported. Cannabinoid receptors (CBRs) CB1 and CB2 , and putative CBRs GPR18 and GPR55, exhibit substantial intracellular expression and there are discrepancies in ligand responsiveness between studies. We investigated whether interactions with RAMPs or MRAPs...

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Format

Research paper

Research format

Journal article

Date created

2023-04

Creator

Glenn, Nathaniel AK / Finlay, David B / Carruthers, Emma R / Mountjoy, Kathleen G / Walker, Christopher S / Grimsey, Natasha L

URL

https://hdl.handle.net/2292/63994

Related subjects

1115 Pharmacology and Pharmaceutical Sciences

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