A structure-based approach to kinase inhibition based on the natural product (-)-TAN-2483B

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Title

A structure-based approach to kinase inhibition based on the natural product (-)-TAN-2483B

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

The natural product (-)-TAN-2483B (1) is a polyketide derived secondary metabolite isolated from the fermentation broth of a filamentous fungus at Takeda Industries, Japan. This compound possesses a densely functionalised furo[3,4-b]pyran-5-one framework rarely seen in natural products, and has displayed inhibitory activity against the c-SRC kinase and parathyroid-induced bone resorption in osteoclasts. Previous work in the Harvey group led to the synthesis of analogue 2, which significantly ...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2020

Creator

Jordan McCone

URL

https://figshare.com/articles/thesis/A_structure-based_approach_to_kinase_inhibition_based_on_the...

Related subjects

Organic chemical synthesis / Chemistry / synthesis / modelling / Degree Level: Doctoral / Degree Name: Doctor of Philosophy / Degree Discipline: Chemistry / School: School of Chemical and Physical Sciences / Organic Chemical Synthesis

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