Rational Design and Synthesis of Covalent Inhibitors for Mycobacterium tuberculosis Isocitrate Lyase

About this item

Title

Rational Design and Synthesis of Covalent Inhibitors for Mycobacterium tuberculosis Isocitrate Lyase

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

During latent tuberculosis infection, Mycobacterium tuberculosis (Mtb), the causative bacterial agent, survives within the intracellular spaces of macrophages by rerouting its metabolic flux towards the glyoxylate shunt. Isocitrate lyase (ICL), the first enzyme of this alternative pathway is intrinsic for the bacteria’s persistence in the body. As such, it presents as an attractive drug target for combatting the disease during its latent phase. However, despite this fact, there are currently ...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2021

Creator

Dan Gabriel Torres

URL

https://figshare.com/articles/thesis/Rational_Design_and_Synthesis_of_Covalent_Inhibitors_for_Myc...

Related subjects

Organic chemical synthesis / Isocitrate Lyase / Tuberculosis / Covalent Inhibitors / School: School of Chemical and Physical Sciences / Degree Discipline: Chemistry / Degree Level: Masters / Degree Name: Master of Drug Discovery and Development / Organic Chemical Synthesis

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