Engineering Nitroreductase Enzymes for Improved Cancer Gene Therapy and Targeted Cellular Ablation

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Title

Engineering Nitroreductase Enzymes for Improved Cancer Gene Therapy and Targeted Cellular Ablation

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

Bacterial nitroreductases are members of a diverse family of oxidoreductase enzymes that can catalyse the bioreductive activation of nitroaromatic compounds, including anti-cancer prodrugs such as CB1954, SN36506 and nitro-CBI-DEI, and antibiotic prodrugs such as metronidazole. These enzymes have diverse applications in medicine and research, including the anti-cancer strategy gene-directed enzyme-prodrug therapy and targeted ablation of nitroreductase-expressing cells in transgenic zebrafish...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2019

Creator

Abigail Victoria Sharrock

URL

https://figshare.com/articles/thesis/Engineering_Nitroreductase_Enzymes_for_Improved_Cancer_Gene_...

Related subjects

Gene and molecular therapy / Medical molecular engineering of nucleic acids and proteins / Nitroreductase / Cancer / Gene therapy / Targeted ablation / Enzyme engineering / Directed evolution / Degree Name: Doctor of Philosophy / Degree Level: Doctoral / Degree Discipline: Biotechnology / School: School of Biological Sciences / Gene and Molecular Therapy / Medical Molecular Engineering of Nucleic Acids and Proteins / Expanding Knowledge in the Biological Sciences / Expanding Knowledge in Technology

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