The growth hormone receptor interacts with transcriptional regulator HMGN1 upon GH-induced nuclear translocation.

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Title

The growth hormone receptor interacts with transcriptional regulator HMGN1 upon GH-induced nuclear translocation.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Growth hormone (GH) actions are mediated through binding to its cell-surface receptor, the GH receptor (GHR), with consequent activation of downstream signalling. However, nuclear GHR localisation has also been observed and is associated with increased cancer cell proliferation. Here we investigated the functional implications of nuclear translocation of the GHR in the human endometrial cancer cell-line, RL95-2, and human mammary epithelial cell-line, MCF-10A. We found that following GH treat...

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Format

Research paper

Research format

Journal article

Date created

2023-04

Creator

Jain, Lekha / Vickers, Mark H / Jacob, Bincy / Middleditch, Martin J / Chudakova, Daria A / Ganley, Austen RD / O'Sullivan, Justin M / Perry, Jo K

URL

https://hdl.handle.net/2292/64026

Related subjects

GHR / HMGN1 / Mass spectrometry / Nuclear / Transcription factor / Cancer / Genetics / 2.1 Biological and endogenous factors / 2 Aetiology / 1 Underpinning research / 1.1 Normal biological development and functioning / 0601 Biochemistry and Cell Biology / 1103 Clinical Sciences / 1112 Oncology and Carcinogenesis

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