Probing the Linker Design of a Conjugate Peptide Vaccine

About this item

Title

Probing the Linker Design of a Conjugate Peptide Vaccine

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

This thesis investigates different chemical approaches to facilitate the exploration of structure-activity relationships related to lipopeptide vaccine CI258, with the overall aim of improving vaccine efficacy and synthetic tractability. The vaccine design comprises a lipid antigen, which functions as a vaccine adjuvant, connected to a peptide antigen via a cleavable and self-immolative linker. In vivo processing of CI258 releases the active vaccine components, with the first step in this pro...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Masters

Date created

2020

Creator

Jasmine Seifert-Simpson

URL

https://figshare.com/articles/thesis/Probing_the_Linker_Design_of_a_Conjugate_Peptide_Vaccine/228...

Related subjects

Organic chemical synthesis / Peptide vaccines / Conjugate vaccines / Linker chemistry / Degree Discipline: Chemistry / Degree Level: Masters / Degree Name: Master of Science / School: School of Chemical and Physical Sciences / Organic Chemical Synthesis

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