The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study.

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Title

The use of brain functional magnetic resonance imaging to determine the mechanism of action of gabapentin in managing chronic pelvic pain in women: a pilot study.

Content partner

The University of Auckland Library

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ResearchSpace@Auckland

Description

ObjectiveTo inform feasibility and design of a future randomised controlled trial (RCT) using brain functional MRI (fMRI) to determine the mechanism of action of gabapentin in managing chronic pelvic pain (CPP) in women.DesignMechanistic study embedded in pilot RCT.SettingUniversity Hospital.ParticipantsTwelve women (18-50 years) with CPP and no pelvic pathology (follow-up completed March 2014).InterventionOral gabapentin (300-2700 mg) or matched placebo.Outcome measuresAfter 12 weeks of trea...

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Format

Research paper

Research format

Journal article

Date created

2019-06

Creator

Seretny, Marta / Murray, Sarah Rose / Whitaker, Lucy / Murnane, Jonathan / Whalley, Heather / Pernet, Cyril / Horne, Andrew W

URL

https://hdl.handle.net/2292/64288

Related subjects

Brain / Humans / Pelvic Pain / Analgesics / Magnetic Resonance Imaging / Pain Measurement / Brain Mapping / Pilot Projects / Adolescent / Adult / Middle Aged / Female / Young Adult / Chronic Pain / Surveys and Questionnaires / Gabapentin / chronic pelvic pain / functional magnetic resonance imaging (fMRI) / pilot randomised control trial (RCT) / pilot study / placebo / Clinical Trials and Supportive Activities / Neurosciences / Pain Research / Clinical Research / Neurological / Science & Technology / Life Sciences & Biomedicine / Medicine, General & Internal / General & Internal Medicine / CLINICAL-TRIALS / CENTRAL SENSITIZATION / 1103 Clinical Sciences / 1117 Public Health and Health Services / 1199 Other Medical and Health Sciences

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