Towards a New Class of Anti-Tuberculosis Drugs: Design and Synthesis of AnPRT TS Analogues

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Title

Towards a New Class of Anti-Tuberculosis Drugs: Design and Synthesis of AnPRT TS Analogues

Content partner

Victoria University of Wellington

Collection

Open Access Victoria University of Wellington

Description

<b>Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacteria tuberculosis (Mtb). In 2021 over 10 million people were diagnosed with TB. It is the number two cause of death behind COVID-19, being attributed to 1.6 million deaths in 2021. Although TB is curable the current multidrug treatment regimens are lengthy, which leads to low adherence and unfavourable treatment outcomes. This has given rise to antibiotic resistance, with 170,000 cases confirmed to be resistant to a...

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Format

Research paper

Research format

Scholarly text / Thesis

Thesis level

Doctoral

Date created

2023

Creator

Emily Mason

URL

https://figshare.com/articles/thesis/Towards_a_New_Class_of_Anti-Tuberculosis_Drugs_Design_and_Sy...

Related subjects

Enzymes / Cheminformatics and quantitative structure-activity relationships / Organic chemical synthesis / Theoretical and computational chemistry not elsewhere classified / Organic Chemistry / Drug Discovery / Infectious Disease / Organic Chemical Synthesis / Enzymatic Assay / Tuberculosis / School: School of Chemical and Physical Sciences / Unit: Ferrier Research Institute / Cheminformatics and Quantitative Structure-Activity Relationships / Theoretical and Computational Chemistry not elsewhere classified / Degree Discipline: Chemistry / Degree Level: Doctoral / Degree Name: Doctor of Philosophy

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