Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing.

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Title

Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing.

Content partner

The University of Auckland Library

Collection

ResearchSpace@Auckland

Description

Adipose browning has demonstrated therapeutic potentials in several diseases. Here, by conducting transcriptomic profiling at the single-cell and single-nucleus resolution, we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue (iWAT) at thermoneutrality or chronic cold condition. All major nonimmune cells within the iWAT, including adipose stem and progenitor cells (ASPCs), mature adipocytes, endothelial cells, Schwann cells, and smooth muscle cells, were rec...

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Format

Research paper

Research format

Journal article

Date created

2023-01

Creator

Liu, Qing / Long, Qiaoyun / Zhao, Jiayu / Wu, Wenjie / Lin, Zexin / Sun, Wei / Gu, Ping / Deng, Tuo / Loomes, Kerry Martin / Wu, Donghai / Kong, Alice PS / Zhou, Jingying / Cheng, Alfred S / Hui, Hannah Xiaoyan

URL

https://hdl.handle.net/2292/65339

Related subjects

Stem Cell Research - Nonembryonic - Non-Human / Stem Cell Research - Nonembryonic - Human / Genetics / Stem Cell Research / 1 Underpinning research / 2.1 Biological and endogenous factors / 1.1 Normal biological development and functioning / 2 Aetiology

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